Ethanol Extract of Miana Leaf (Coleus atropurpureus Benth) As Analgetic Antiinflamation in Rats (Rattus novergicus)

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage inhibit cyclooxygenase, which the first pathway for synthesis pain mediators prostaglandins. Objectives: This study aims determine effectiveness ethanol extract Benth) (EEML) analgesic anti-inflammatory in rats (Rattus novergicus). Material Methods: used Pre-Posttest-Only Control Group Design, twenty male were divided into 5 groups namely negative control, positive control was given diclofenac sodium, treatment with EEML dose 150 mg/kgBW, 300 600 mg/kgBW. Test Antiinflammatory uses Rat Hind Paw Edema method where condition induced 5% egg white subplantar. measurement edema rat feet caliper every 30 minutes hours. While testing nociception test evaluates responses Staggering Gait, Vocalization, Writhing. Results: results inflammatory parameters analyzed One Way Anova width foot Kruskal Walis thickness foot. observing test. Conclusions: concluded that has especially at mg/kg BW are non-significant (p> 0.05) group (sodium diclofenac).